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Salud, Ciencia y Tecnología Metaverse Basic and Applied Research Data & Metadata Interdisciplinary Rehabilitation Salud, Ciencia y Tecnología - Serie de Conferencias Community and Interculturality in Dialogue Seminars in Medical Writing and Education Health Leadership and Quality of Life Gamification and Augmented Reality Southern perspective / Perspectiva austral
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Original
Published: 2023-12-25
DOI: https://doi.org/10.56294/sctconf2023594

Promising role of molecular biomarkers in cytological samples for early detection of cervical cancer: a systematic review

By
Moina Veloz Alvaro Paul ,
Moina Veloz Alvaro Paul

Universidad Técnica de Ambato, Facultad de Ciencias de la Salud. Ambato, Ecuador

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Cumanda Elizabeth Endara Arias ,
Cumanda Elizabeth Endara Arias

Hospital del Día “Señor de las Misericordias”, Servicio de Gineco-Obstetricia. Riobamba, Ecuador

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Abstract

Introduction: Cervical cancer is a preventable and treatable disease. Early detection is crucial for improving patient prognosis and quality of life. The Pap smear has limitations in sensitivity and specificity. Molecular biomarkers in cytological samples can improve early detection. Method: A literature review was conducted on the evaluation of molecular biomarkers in cytological samples for the early detection of cervical cancer. Studies were searched in PubMed, Scopus, and Web of Science. Results: We identified 6 studies that evaluated various molecular biomarkers, including HPV DNA, DNA methylation, miRNAs, and proteins. The studies demonstrated that molecular biomarkers have a higher sensitivity and specificity than the Pap smear for detecting cervical cancer. Conclusion: The evaluation of molecular biomarkers in cytological samples is a promising tool for the early detection of cervical cancer. Further research is needed to standardize detection techniques, validate their clinical utility in different populations and contexts, and reduce the cost of testing.

Keywords:

Cervical cancer,
Molecular biomarkers,
Pap smear,
Human papillomavirus (HPV),
DNA methylation,
MicroRNA (miRNA),

How to Cite

1.
Alvaro Paul MV, Endara Arias CE. Promising role of molecular biomarkers in cytological samples for early detection of cervical cancer: a systematic review. Salud, Ciencia y Tecnología - Serie de Conferencias [Internet]. 2023 Dec. 25 [cited 2024 Jul. 1];2:594. Available from: https://conferencias.saludcyt.ar/index.php/sctconf/article/view/594

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The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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IV Jornadas de Fundamentos y Aplicaciones de la Interdisciplina (JFAI2023)
Vol. 2 (2023)
See full issue

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