Consumo materno de alcohol y alteraciones en la descendencia perinatal: aproximaciones desde un modelo experimental para el abordaje de las implicancias en el desarrollo temprano feto-placentario

Camila  Barril; Gisela  Gualdoni; Patricia Jacobo; Liliana Pacheco Rodríguez; Elisa Cebral

doi:10.56294/sctconf202395

Conference abstract

Published: 2023-04-24

DOI: https://doi.org/10.56294/sctconf202395

Maternal alcohol consumption and alterations in the perinatal offspring: Approaches from an experimental model for the approach of implications in early fetus-placentary development

Abstract

Chronic, moderate-sex consumption, alcohol during pregnancy, high prevalence in Argentina and in the world, produces intrauterine growth delay (RCIU), high risk of development of fetal alcoholic spectrum disorder (FASD) and various diseases in the descendants. In recent years, it has been proposed that both RCIU and congenital heart disease and chronic adult diseases typical of FASD are associated or caused by placental alteration. Alcohol exposure can affect, together with the epigenoma of the placenta, various molecular mechanisms of placental angiogenesis in early and/or term stages. However, the effects of moderate alcohol berestational consumption on fetal development are still little known. This type of intake, from before pregnancy and to early organogenesis, represents a social consumer who continues with the intake during the first month of pregnancy, when he still does not take knowledge about his state of gravity. In this context, our laboratory has established an experimental murine model of maternal alcohol consumption to study the effects on embryo-fetus-placentary development, and the molecular mechanisms involved. In relation to this, our recent evidence shows that the perigestational consumption of alcohol to early stages of gestation induces morphological and skeletal abnormalities and fetal heart disease along with growth defects, poor vascularization and alterations in the expression and activity of angiogenic factors of the placenta . In this framework of studies, we suggest that FASD manifestations originate early and are linked to anomalous early placentation, playing a preponderant role the vascularization defects of the maternal face (decidua) and the development and growth of the fetal face (labyrinth) during early pregnancy in the Murino Model of Maternal Exhibition to Alcohol.

Keywords:

Chronic Alcohol Consumption,

Fetal Alcoholic Spectrum Disorder,

Placental Angiogenesis,

Experimental Murino Model,

How to Cite

Barril C, Gualdoni G, Jacobo P, Pacheco Rodríguez L, Cebral E. Maternal alcohol consumption and alterations in the perinatal offspring: Approaches from an experimental model for the approach of implications in early fetus-placentary development. Salud, Ciencia y Tecnología - Serie de Conferencias [Internet]. 2023 Apr. 24 [cited 2024 Jul. 1];2:95. Available from: https://conferencias.saludcyt.ar/index.php/sctconf/article/view/95

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The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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IV Jornadas de Fundamentos y Aplicaciones de la Interdisciplina (JFAI2023)

Vol. 2 (2023)

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