Evaluación del programa de detección de malformaciones congénitas por cuantificación de alfafetoproteína. Sandino

Pedro Antonio Ramírez Sosa; Yarelis Prieto Hernández; Rosa María Ajete Rodríguez; Yenia Ledesma Vega; Yusimi Martínez Fernández; Yeisleidy González Borges

doi:10.56294/sctconf2022284

Original

Published: 2022-12-11

DOI: https://doi.org/10.56294/sctconf2022284

Evaluation of the congenital malformation screening program by alpha-fetoprotein quantification. Sandino

Abstract

Introduction: in recent years, the Program for Diagnosis and Prevention of Genetic Diseases has contributed to reduce the infant mortality rate and to improve the quality of life of the population.

Objectives: to evaluate the prenatal diagnosis program for congenital malformations, through the quantification of alpha-fetoprotein in maternal serum.

Methods: a descriptive, prospective, longitudinal study was conducted on the total number of pregnant women from January 1, 2000 to December 31, 2018, in the two Health Areas of the Sandino municipality using data from the municipal and provincial Genetics consultation.

Results: the coverage of the AFPSM program was 98,13 % and of them 6,46 % resulted high, patients without explainable cause were the predominant ones with 33,93 % followed by threatened abortion and low maternal weight with 22,92 and 21,57 % respectively, 5,84 % were due to some type of fetal malformation. The most frequent fetal malformations were neural tube closure defects and anterior wall defects with 34,61 and 26,92 % respectively.

Conclusions: the prenatal diagnosis program for congenital malformations through the determination of alpha-fetoprotein in maternal serum has been improved over time, as shown by the increase in screening, the number and type of malformations diagnosed, as well as the decrease in infant mortality due to this type of malformation.

Keywords:

Prenatal Diagnosis,

Abnormalities/Diagnosis,

Alpha-Fetoprotein,

How to Cite

Ramírez Sosa PA, Prieto Hernández Y, Ajete Rodríguez RM, Ledesma Vega Y, Martínez Fernández Y, González Borges Y. Evaluation of the congenital malformation screening program by alpha-fetoprotein quantification. Sandino. Salud, Ciencia y Tecnología - Serie de Conferencias [Internet]. 2022 Dec. 11 [cited 2024 Jun. 29];1:284. Available from: https://conferencias.saludcyt.ar/index.php/sctconf/article/view/284

Copyright Notice

The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.

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